Research: The Inherent Rhythmic Motion of the Cranial Bones.
Cranial bone motion has been the most controversial phenomenon of the Primary Respiratory Mechanism (PRM), but there is ample evidence that the cranial bones do rhythmically move a small but definite amount.
Historically, cranial bone motion was considered an anatomic impossibility. Respected scientists, anatomists, and anthropologists have always assumed that the cranial bones fuse and cannot move.
- Most often cited are the works of Bolk,3 Melsen,4 Perizonius,5 Cohen,6 and Sahni et al.7
However, a thorough examination of the experimental data gives a totally different point of view.
- Todd and Lyon’s8,9 study is sited as a precedent for all of the aforementioned
anthropologists and anatomists (with the exception of Bolk3), assuming that
cranial bones normally fuse and are therefore immobile.
Upon examination of Todd and Lyon’s data, the conclusion that cranial bones normally fuse is certainly in question.
- Dart10 states, “In interpreting this data, it must be noted that Todd and Lyon were attempting to establish a pattern for ‘normal’ sutural closure, and they discounted [eliminated] data, due to prolonged sutural patency[non-closure].”
- Singer11 gives further evidence to doubt the concept of universal sutural fusion. He found a high percentage of specimens with much less closure than Todd and Lyon’s.
- Pritchard et al.12 commented in the 1950s that obliteration of sutures and synostosis (total closure) of adjoining bones, if it happens at all, occurs usually after all growth has ceased. In man and most laboratory animals sutures may never completely close.
- Sabini and Elkowitz13 reviewed 36 human cadaver skulls ranging in age from 56 to 101 years of age, all well above the age when bone growth is complete. Their findings of a significant amount of sutural patency (non-fusion) challenge the theory that all cranial sutures are fused and cannot move.
- Retzlaff et al.14,15 identified sutural elements contradicting ossification and demonstrated the presence of vascular and neural structures in the sutures. The study stated, “…sutures remain as clearly identifiable structures even in the oldest samples.”
- Retzlaff et al16 also showed the presence of nerve and vascular tissue large enough to supply connective tissue in the sutures. Nerve endings were traced from the sagittal suture (in the top of the head) to the neck. The existence of these structures within the cranial sutures strongly supports the idea that these sutures remain patent and mobile.
Cranial bone motion in animals is well documented:
- Michael and Retzlaff17 demonstrated cranial bone (parietal) mobility in the squirrel monkey.
- Heisey and Adams18-20 demonstrated cat parietal bone motion, in the range of 200-300 microns, induced by laboratory controlled changes in the Cerebro-Spinal Fluid (CSF) volume.
- Jaslow21 demonstrated in goat skulls (Capra hircus), that patent (non-fused) cranial sutures in adult animals may play a role in shock absorption and re-distribution of forces directed against the skull.
Cranial bone motion in humans is also well documented:
- Frymann22 developed a non-invasive apparatus for mechanically measuring the changes in cranial diameter. On the basis of her extensive recordings, she was able to conclude that a rhythmic pattern of cranial bone mobility exists and occurs at a rate that is different than that of thoracic respiration. This work was later cited by NASA scientists.
- Heifetz and Weiss,23 using a strain gauge device, demonstrated cranial vault (bones of the top of the head) expansion associated with a rise in intracranial pressure (ICP) in two comatose patients.
- Oleski and Smith24 measured pre- and post-treatment changes in cranial bone position utilizing x-ray technology. The percentage of subjects with identifiable changes are:
There are plans to expand this research utilizing a larger number of subjects.
Russian Space Research
Assessment of cranial bone motion carried out by the Russian cosmonaut programs used various types of radiographic (x-ray) and ultrasound equipment.
- Moskalenko25,26 first published research on cats in space that described wave phenomenon similar to earlier discussions of "third order waves" in glial cells.
After being introduced to OCF, Moskalenko and associates carried out several studies which illustrated cranial bone motion:
- Moskalenko27 demonstrated, via NMR tomograms, cranial bone motion between 380 microns to 1 mm, and cranial cavity volume increases by 12-15 mL, with a rhythmicity of 6-14 cycles per minute.
- Moskalenko28 used Bioimpedence measurements and Transcranial Ultrasound Doppler Echography to show slow oscillations (back and forth motion) of the cranial bones at 5-12 cycles per minute. Moskalenko demonstrated that these oscillations, “…were of intracranial origin and were related to the mechanisms of regulation of the blood supply to and oxygen consumption by cerebral tissue, as well as with the dynamics of CSF circulation.”
Together, Moskalenko and Frymann29 carried this work toward the formulation of a theory that explains the physiology of the PRM.
US Space Research
In the mid-1990s NASA carried out research and developed an ultrasound device using pulse-phase locked loop (PPLL) technology with sensitivity to 0.1 µm, to more precisely assess intracranial anatomy and physiology.30-34
- Ballard,et al.31 carried out a study on two fresh cadavers. Saline was manually pumped into the internal spaces of the brain (ventricles) at a rate of one cycle per second, increasing the Intra-Cranial Pressure (ICP) by 15 mm Hg, and expanding the skull 0.929 mm. These findings were interpreted by the authors as similar to those found by Heisey and Adams,18 Hiefetz and Weiss,23 and Frymann.22
- Ueno, et al.32 utilized the PPLL device to demonstrate that “when intracranial pressure increases, arterial pulsation produces a higher amplitude ICP pulsation [stronger]. Increased amplitude of ICP pulsations will be manifested by larger fluctuations in distance across the skull.”
In their summary, the NASA research team stated, “Although the skull is often assumed to be a rigid container with a constant volume, many researchers have demonstrated that the skull moves on the order of a few µm in association with changes in intracranial pressure.” 33,34
Recent Osteopathic Research on Cranial bone Motion
When palpatory assessment of cranial bone motion is compared with simultaneous Laser Doppler Flowmetry technology, striking correlations have been found.
- Nelson, Sergueef and Glonek35-38 report that Traube-Hering and Meyer oscillations can now be assessed. They describe oscillations which occur about 4 to 6 cycles per minute. These oscillations occur at the same time the osteopathic physician reports a certain phase of the cranial bone motion.
Instrument recordings of physiologic activity which correspond to clinical palpatory experience provide strong support for the concept of cranial bone motion and the PRM in general. This line of research is continuing.
Substantial support for life-long sutural patency and mobility of cranial sutures in healthy human beings is well established within the scientific and medical literature. Cranial bones can move small amounts, and do posses inherent rhythmic motion.
Left to Right: Viola M. Frymann DO, Yuri Moskalenko PhD, Kenneth Nelson DO,
Tom Glonek PhD, Toshiaki Ueno MD PhD, Frank Willard PhD.
The Cranial Academy and Sutherland Cranial Teaching Foundation sponsored a “PRM Research Symposium” in October 2003. Pictured is a panel featuring several of the most outstanding cranial osteopathic researchers.
- Ferre JC, Barbin JY. The osteopathic cranial concept: Fact or fiction. Surg Radiol Anat. 1991;13:165-170.
- Hartman SE, Norton JM. Interexaminer reliability and cranial osteopathy. Sci Rev Altern Med. 2002;6:23-34.
- Bolk L. On the premature obliteration of sutures in the human skull. Am J Anat. 1915;17:495-523.
- Melsen B. Time and mode of closure of the spheno-occipital synchondrosis determined on human autopsy material. Acta Anat. 1972;83:112-118.
- Perizonius WRK. Closing and non-closing sutures in 256 crania of known age and sex from Amsterdam (A.D. 1883-1909). J Hum Evol. 1984; 13:201 -216.
- Cohen Jr MM. Sutural biology and the correlates of craniosynostosis. Am J Med Genet. 1993;47:581-616.
- Sahni D, Jit I, Neelam, Suri S. Time of fusion of the basisphenoid with the basilar part of the occipital bone in northwest Indian subjects. Forensic Sci Int. 1998;98:41-45.
- Todd TW, Lyon DW. Endocranial suture closure, its progress and age relationship. I. Adult males of white stock. Am J Phys Anthrop. 1924;7:325-384. II. Am J Phys Anthrop 1925;8:23-45.
- Todd TW, Lyon DW. Endocranial suture closure, its progress and age relationship. III Endocranial closure in adult males of negro stock. Am J Phys Anthrop 1925;8:47-71. IV Am J Phys Anthrop. 1925;8:149-68.
- Dart P. An overview of research supporting the fundamental concepts of osteopathy in the cranial field. Unpublished manuscript.
- Singer R. Estimation of age from cranial suture closure: Report on its unreliability. J Forensic Med. 1953;1:52-59.
- Pritchard JJ, Scott JH, Girgis FG. The structure and development of cranial and facial sutures. J Anat. 1956;90:73-86.
- Sabini RC, Elkowitz DE. Significant differences in patency among cranial sutures. J Am Osteopath Assoc. 2006;106:600-604.
- Retzlaff EW, Upledger JE, Mitchell FL Jr, Walsh J. Aging of cranial sutures in humans. Anat Rec 1979;193:663 (abst).
- Retzlaff EW, Mitchell FL Jr, Upledger JE, et al. Neurovascular mechanisms in cranial sutures. J Am Osteopath Assoc. 1980; 80:218-219 (abst).
- Retzlaff EW, Jones L, Mitchell FL Jr, et al. Possible autonomic innervation of cranial sutures of primates and other animals. Brain Res 1973;58:470-477 (abst).
- Michael DK, Retzlaff EW. A preliminary study of cranial bone movement in the squirrel monkey. J Am Osteopath Assoc. 1975;74:866-869.
- Heisey SR, Adams T. Role of cranial bone mobility in cranial compliance. Neurosurgery. 1993;33(5):869-876.
- Heisey SR, Adams T. A two compartment model for cranial compliance. J Am Osteopath Assoc. 1995;95:547.
- Adams T, Heisey RS, Smith MC, Briner BJ. Parietal bone mobility in the anesthetized cat. J Am Osteopath Assoc. 1992;92(5):599-622.
- Jaslow CR. Mechanical properties of cranial sutures. J Biomechanics. 1990;23(4):313-321.
- Frymann VM. A study of the rhythmic motions of the living cranium. J Am Osteopath Assoc. 1971;70:1-18.
- Heifitz MD, Weiss M. Detection of skull expansion with increased intracranial pressure. J Neurosurg. 1981;55:811-812.
- Oleski SL, Smith GH, Crow WT. Radiographic evidence of cranial bone mobility. J Craniomandib Pract. 2002;20(1):34-38.
- Moskalenko YE, Cooper H, Crow H, Walter WG. Variation in blood volume and oxygen availability in the human brain. Nature. 1964;202(4926):59-161.
- Moskalenko YE, Weinstein GB, Demchenko IT, et al. Biophysical aspects of cerebral circulation. Oxford: Pergamon Press; 1980.
- Moskalenko YE, Kravchenko TI, Gaidar BV, et al. Periodic mobility of cranial bones in humans. Human Physiology. 1999;25(1):51-58.
- Moskalenko YE, Frymann VM, Weinstein GB, et al. Slow rhythmic oscillations within the human cranium: phenomenology, origin, and informational significance. Human Physiology. 2001;27(2):171-178.
- Moskalenko YE, Frymann VM, Kravchenko T. A modern conceptualization of the functioning of the primary respiratory mechanism. In King HH. (Ed) Proceedings of international research conference: Osteopathy in Pediatrics at the Osteopathic Center for Children in San Diego, CA 2002. American Academy of Osteopathy, Indianapolis, IN, 2005;12-31.
- Hargens AR. Noninvasive intracranial pressure (ICP) measurement. 1999 Space Physiology Laboratory. http://spacephysiology.arc.nasa.gov/projects/icp.html
- Ballard RE, Wilson M, Hargens AR, et al. Noninvasive measurement of intracranial volume and pressure using ultrasound. American Institute of Aeronautics and Astronautics Life Sciences and Space Medicine Conference. Book of Abstracts, pp. 76-77, Houston, TX, 3-6 March 1996.
- Ueno T, Ballard RE, Cantrell JH, et al. Noninvasive estimation of pulsatile intracranial pressure using ultrasound. NASA Technical Memorandum 112195. 1996.
- Ueno T, Ballard RE, Shuer LM, Yost WT, Cantrell, Hargens AR. Noninvasive measurement of pulsatile intracranial pressure using ultrasound. Acta Neurochir. 1998;[Suppl]71:66-69.
- Ueno T, Ballard RE, Macias BR, et al. Cranial diameter pulsation measured by non-invasive ultrasound decrease with tilt. Aviation, Space and Environmental Medicine. 2003;74(8):882-885.
- Nelson KE, Sergueff N, Lipinski CL, Chapman A, Glonek T. The cranial rhythmic impulse related to the Traube-Hering-Meyer oscillation: Comparing laser-Doppler flowmetry and palpation. J Am Osteopath Assoc. 2001;101(3):163-173.36.
- Sergueef N, Nelson KE, Glonek T. Changes in the Traube-Hering-Meyer wave following cranial manipulation. Amer Acad Osteop J. 2001;11:17.
- Nelson KE, Sergueff N, Glonek T. The effect of an alternative medical procedure upon low-frequency oscillation in cutaneous blood flow velocity. J Manipulative Physiol Ther. 2006;29:626-636.
- Nelson KE, Sergueff N, Glonek T. Recording the rate of the cranial rhythmic impulse. J AM Osteopath Assoc. 2006;106(6):337-341.